邓子新
教授
微生物遗传学
Email: zxdeng@sjtu.edu.cn

上海交通大学微生物代谢国家重点实验室主任
中国微生物学会理事长
中国科学院院士, 第三世界科学院院士 (Fellow, TWAS), 美国微生物科学院院士 (Fellow, AAM)

简历：
       1982年毕业于华中农业大学微生物专业；1988年于英国 John Innes 研究中心获博士学位；1988年起在华中农业大学任教，历任讲师、副教授、教授；2000年始任上海交通大学教授、博导。 2001-2003年 兼美国康乃尔大学客座教授。国家973项目首席科学家，国家自然科学基金委员会生命科学部第四届专家咨询委员会委员和学科评审组成员。《Chemistry & Biology》,《BMC Microbiology》,《Process Biochemistry》等数十个国内外刊物编辑或编委。2005 年当选为中国科学院院士；2006 年当选为第三世界科学院院士(Fellow, TWAS)；2010年当选美国微生物科学院院士(Fellow, AAM)。
       长期从事微生物代谢的分子生物学研究，主攻放线菌遗传学及抗生素生物合成的化学生物学，打开DNA硫化修饰新领域，在国内外学术刊物上发表170余篇学术论文。先后获得国家自然科学二等奖（2008）、上海市（2004）和农业部科技进步一等奖（1994）、教育部自然科学二等奖(2007)、“瑞典国王 Baudiouin奖”(1997)等。蝉联2005、2006年中国高校十大科技进展,获评《环球科学》2007全球十大科学新闻。1990年以来，相 继被授予国家级有突出贡献的专家(1991)、霍英东基金会“青年教师奖”(1991)、首届“中国青年科学家奖”提名奖(1993)、首届国家杰出青年 科学基金(1994)、“中国青年科技奖”(1994)、“上海市十大科技创新英才”(2005)、上海市科技领军人物(2006)、上海市劳动模范 (2007)、全国五一劳动奖章(2008)、全国先进工作者(2010)、何梁何利奖（2012）等。

研究方向:
1.    DNA硫修饰生物学
2.    微生物次级代谢产物的生物合成

发表论文:

1. Gou L, Wu Q, Lin S, Li X, Liang J, Zhou X, An D, Deng Z, Wang Z. Mutasynthesis of pyrrole spiroketal compound using calcimycin 3-hydroxy anthranilic acid biosynthetic mutant. Appl Microbiol Biotechnol. 2013 May.
2. Xu F, Kong D, He X, Zhang Z, Han M, Xie X, Wang P, Cheng H, Tao M, Zhang L, Deng Z, Lin S. Characterization of streptonigrin biosynthesis reveals a cryptic carboxyl methylation and an unusual oxidative cleavage of a N-C bond. J Am Chem Soc. 2013, 135(5):1739-48.
3. Bi D, Liu L, Tai C, Deng Z, Rajakumar K, Ou HY. SecReT4: a web-based bacterial type IV secretion system resource. Nucleic Acids Res. 2013, 41:D660-5.
4. Xie X, Liang J, Pu T, Xu F, Yao F, Yang Y, Zhao YL, You D, Zhou X, Deng Z, Wang Z. Phosphorothioate DNA as an antioxidant in bacteria. Nucleic Acids Res. 2012, 40(18):9115-24.
5. Wu J, Li L, Deng Z, Zabriskie TM, He X. Analysis of the mildiomycin biosynthesis gene cluster in Streptoverticillum remofaciens ZJU5119 and characterization of MilC, a hydroxymethyl cytosyl-glucuronic acid synthase. Chembiochem. 2012, 13(11):1613-21.
6. Chen L, Wang Y, Guo H, Xu M, Deng Z, Tao M. High-throughput screening for Streptomyces antibiotic biosynthesis activators. Appl Environ Microbiol. 2012 Jun;78(12):4526-8.
7. Zhai L, Lin S, Qu D, Hong X, Bai L, Chen W, Deng Z. Engineering of an industrial polyoxin producer for the rational production of hybrid peptidyl nucleoside antibiotics. Metab Eng. 2012, 14(4):388-93.
8. Zhang W, Wang L, Kong L, Wang T, Chu Y, Deng Z, You D. Unveiling the post-PKS redox tailoring steps in biosynthesis of the type II polyketide antitumor antibiotic xantholipin. Chem Biol. 2012, 19(3):422-32.
9. Cheng L, Chen W, Zhai L, Xu D, Huang T, Lin S, Zhou X, Deng Z. Identification of the gene cluster involved in muraymycin biosynthesis from Streptomyces sp. NRRL 30471. Mol Biosyst. 2011, 7(3):920-7
10. Wang L, Chen S, Vergin KL, Giovannoni SJ, Chan SW, DeMott MS, Taghizadeh K, Cordero OX, Cutler M, Timberlake S, Alm EJ, Polz MF, Pinhassi J, Deng Z, Dedon PC. DNA phosphorothioation is widespread and quantized in bacterial genomes. Proc Natl Acad Sci U S A. 2011, 108(7):2963-8.
11. Gu TP, Guo F, Yang H, Wu HP, Xu GF, Liu W, Xie ZG, Shi L, He X, Jin SG, Iqbal K, Shi YG, Deng Z, Szabó PE, Pfeifer GP, Li J, Xu GL. The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes. Nature. 2011, 477(7366):606-10.
12. Chen S, Wang L, Deng Z. Twenty years hunting for sulfur in DNA. Protein Cell 2010, 1(1):14-21.
13. Liu G, Ou HY, Wang T, Li L, Tan H, Zhou X, Rajakumar K, Deng Z, He X. Cleavage of phosphorothioated DNA and methylated DNA by the type IV restriction endonuclease ScoMcrA. PLoS Genet. 2010, 6(12):e1001253.
14. Zhao C, Huang T, Chen W, Deng Z. Enhancement of the diversity of polyoxins by a thymine-7-hydroxylase homolog outside the polyoxin biosynthesis gene cluster. Appl Environ Microbiol. 2010, 76(21):7343-7.
15. Zhao C, Coughlin JM, Ju J, Zhu D, Wendt-Pienkowski E, Zhou X, Wang Z, Shen B, Deng Z. Oxazolomycin biosynthesis in Streptomyces albus JA3453 featuring an "acyltransferase-less" type I polyketide synthase that incorporates two distinct extender units. J Biol Chem. 2010, 285(26):20097-108.
16. Xu T, Yao F, Zhou X, Deng Z, You D. A novel host-specific restriction system associated with DNA backbone S-modification in Salmonella. Nucleic Acids Res. 2010, 38(20):7133-41
17. Zhou Y, Li J, Zhu J, Chen S, Bai L, Zhou X, Wu H, Deng Z. Incomplete beta-ketone processing as a mechanism for polyene structural variation in the FR-008/candicidin complex. Chem Biol. 2008, 15(6):629-38.
18. Wang L, Chen S, Xu T, Taghizadeh K, Wishnok JS, Zhou X, You D, Deng Z, Dedon PC.Phosphorothioation of DNA in bacteria by dnd genes. Nat Chem Biol. 2007, 3(11):709-10.
19. He X, Ou HY, Yu Q, Zhou X, Wu J, Liang J, Zhang W, Rajakumar K, Deng Z. Analysis of a genomic island housing genes for DNA S-modification system in Streptomyces lividans 66 and its counterparts in other distantly related bacteria. Mol Microbiol. 2007, 65(4):1034-48.
20. Liu T, Lin X, Zhou X, Deng Z, Cane DE. Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic nanchangmycin. Chem Biol. 2008 May;15(5):449-58.
21. Ou HY, He X, Harrison EM, Kulasekara BR, Thani AB, Kadioglu A, Lory S, Hinton JC, Barer MR, Deng Z, Rajakumar K. MobilomeFINDER: web-based tools for in silico and experimental discovery of bacterial genomic islands. Nucleic Acids Res. 2007, 35:W97-W104.
22. Liang J, Wang Z, He X, Li J, Zhou X, Deng Z. DNA modification by sulfur: analysis of the sequence recognition specificity surrounding the modification sites. Nucleic Acids Res. 2007, 35(9):2944-54.
23. Deng Z, Bai L. Antibiotic biosynthetic pathways and pathway engineering--a growing research field in China. Nat Prod Rep. 2006, 23(5):811-27.
24. Liu T, You D, Valenzano C, Sun Y, Li J, Yu Q, Zhou X, Cane DE, Deng Z. Identification of NanE as the thioesterase for polyether chain release in nanchangmycin biosynthesis. Chem Biol. 2006, 13(9):945-55.
25. Zhao C, Ju J, Christenson SD, Smith WC, Song D, Zhou X, Shen B, Deng Z. Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning the oxazolomycin biosynthetic gene cluster from Streptomyces albus JA3453. J Bacteriol. 2006, 188(11):4142-7.
26. Bai L, Li L, Xu H, Minagawa K, Yu Y, Zhang Y, Zhou X, Floss HG, Mahmud T, Deng Z. Functional analysis of the validamycin biosynthetic gene cluster and engineered production of validoxylamine A. Chem Biol. 2006, 13(4):387-97.
27. Zhou X, He X, Liang J, Li A, Xu T, Kieser T, Helmann JD, Deng Z. A novel DNA modification by sulphur. Mol Microbiol. 2005, 57(5):1428-38.
28. Zhu D, He X, Zhou X, Deng Z. Expression of the melC operon in several Streptomyces strains is positively regulated by AdpA, an AraC family transcriptional regulator involved in morphological development in Streptomyces coelicolor. J Bacteriol. 2005, 187(9):3180-7.