康前进,男,1981年8月出生,1999年9月至2003年7月就读于安徽中医学院,获理学学士学位;2003年9月至2008年5月就读于中科院昆明植物研究所,获理学博士学位。2008年7月至2010年12月在上海交通大学生命科学技术学院,进行博士后研究工作,合作导师为邓子新和白林泉教授,主要从事安莎类抗生素生物合成及相关酶学研究。2010年底,以助理研究员的身份加入到上海交通大学微生物代谢国家重点实验室。2013年年初晋升为副研究员。现在主要开展了微生物产生的重要抗生素的生物合成及合成生物学研究,微生物活性物质的资源挖掘和功能基因组学研究等。
Figure 3 Structures of thiopeptides. (Kang, et al. Biotechnol Adv. 2012)
发表论文:1. Biosynthesis of 3,5-AHBA-derived natural products. Kang Qianjin, Shen Yuemao, and Bai Linquan*, Nat Prod Rep, 2012, 29: 243-263.
2. Unveiling the Biosynthetic Puzzle of Destruxins in Metarhizium Species. Wang, Bing, Kang, Qianjin, Lu, Yuzhen; Bai, Linquan, and Wang, Chengshu*, Proc Natl Acad Sci USA, 2012, 109: 1287-1292.
3. Toward steadfast growth of antibiotic research in China: From natural products to engineered biosynthesis. Kang Qianjin, Bai Linquan*, and Deng Zixin, Biotechnol Adv,2012, 30(6):1228-41
4. Cloning and functional analysis of the naphthomycin biosynthetic gene cluster in Streptomyces sp. CS. Wu Yingying, Kang Qianjin (co-first author), Shen Yuemao, Su Wenjin and Bai Linquan*, Mol Biosyst., 2011, 7: 2459-2469.
5. N-methylation of the Amide Bond by Methyltransferase Asm10 in Ansamitocin Biosynthesis. Wu Yingying, Kang Qianjin (co-first author), Shang Guangdong, Spiteller Peter, Carroll Brian, Yu Tin-Wein, Su Wenjin, Bai Linquan*, and Floss Heinz G., Chembiochem, 2011, 12: 1759-1766.
6. Chemical Constituents from the Stem Bark of Trewia nudiflora L. and their Antioxidant Activities. Kang Qianjin, Yang Xianwen, Wu shaohua, Ma Yanling, Li Ling, and Shen Yuemao*, Planta Medica, 2008, 74: 445-448.
7. Cardenolides and Cardiac Aglycone from the Stem Bark of Trewia nudiflora L. Kang Qianjin, Zhao Peijin, He Hongping, and Shen Yuemao*, Helv Chim Acta, 2005, 88: 2781-2787.
8. Cloning and Characterization of the Polyether Salinomycin Biosynthesis Gene Cluster of Streptomyces albus XM211. Jiang Chunyan , Wang Hougen, Kang Qianjin, Liu Jing and Bai Linquan*, Appl. Environ. Microbiol.2012, 78(4):994.
9. Dual carbamoylations on the polyketide and glycosyl moiety by Asm21 result in extended ansamitocin biosynthesis. Li Yan, Zhao Peiji, Kang Qianjin, Ma Juan, Bai Linquan*, et al., Chem Biol., 2011, 18: 1571-1580.
10. Elucidation of Piericidin A1 biosynthetic locus revealed a thioesterase-dependent mechanism of α-pyridone ring formation. Liu Qian, Yao Fen, Chooi Yit Heng, Kang Qianjin, Xu Wei, et al. You Delin*. Chem Biol. 2012, 24;19(2):243-53.
11. Characterization of the Azinomycin B Biosynthetic Gene Cluster Revealing a Different Iterative Type I Polyketide Synthase for Naphthoate Niosynthesis. Zhao Qunfei, He Qingli, Ding Wei, Tang Mancheng, Kang Qianjin, Yu Yi, Deng Wei, Zhang Qi, Fang Jie, Tang Gongli, and Liu Wen. Chem Biol., 2008, 15:693-705.