Lutz Heide



Professor Dr. rer. nat. Lutz Heide
Pharmaceutical Institute, University of Tübingen, 72076 Tübingen, Germany
 Personal Details                                Contact Details
 Date of Birth: 16th May 1955             Telephone: +49-7071-2972460
 Nationality: German                            FAX: +44-7071-295250
Education and Research Experience

Licensed Pharmacist, University of Münster, Germany, 1978

Ph.D. Plant and Bacterial Metabolism, University of Münster, 1981 (E. Leistner)
Senior Pharmacist Adviser, Ministry of Health, Somalia, 1982-85
PostDoc (Humboldt Fellow), Plant Biotechnology, Kyoto University, Japan, 1985-87 (M. Tabata)
Assistant Professor, Pharmaceutical Biology, University of Bonn, Germany, 1987-90
DFG Heisenberg Scholar, University of Bonn, Germany, 1990-91
Associate Professor, Pharmaceutical Biology, University of Freiburg, Germany, 1991-94
Full Professor (C4), Pharmaceutical Biology , University of Tübingen, Germany, 1994-present
 April-Sep. 1996:   Sabbatical with Dr. H. G. Floss, University of Washington, Seattle, USA
 March-Sep.2005             Sabbatical with Prof. J. Noel, Salk Insitute, La Jolla, California, USA
Research theme: Genetic engineering of antibiotic biosynthesis in Streptomyces
Professional activities (selected)
2007-present           Associate Editor of Microbiology
2004-2007               Coordinator of the EC-funded Research Consortium CombiGyrase
2004-present        Member of the Selection Committees of the German Academic Exchange Service (DAAD) for the Asia/Pacific Region
2007-2008               Member of the International Scientific Committee of the International Biotechnology Symposium, Dalian, China
2008-2009          Member of the International Advisory Board of the Fifteenth International Symposium on the Biology of Actinomycetes (ISBA'15), Shanghai, China
Selected research grants
European Community, Integrated Project No. 005224 “ActinoGEN: Integrating Genomics-Based Applications to Exploit Actinomycetes as a Resource for New Antibiotics”. Coordinator P. Dyson, Swansea, UK. Total Budget € 9.4 M, Tübingen Budget € 0.95 M.
European Community, Specific targeted research projec No. 503466 “CombiGyrase: Development of new gyrase inhibitors by combinatorial biosynthesis”. Coordinator L. Heide, Tübingen, Germany. Total Budget € 1.6 M, Tübingen Budget € 0.33 M
German Research Foundation (DFG), Collaborative Research Center 766 “The Bacterial Cell Envelope: Structure, Function and Infection Interface”: “Influx and efflux of new aminocoumarin derivatives across the bacterial cell envelope”. With K. Hantke. € 0.4 M.
German Research Foundation (DFG), Priority Progamme SPP 1152 “Evolution of metabolic diversity”: “Evolution of a new class of aromatic prenyltransferases of secondary metabolism”. € 0.3 M.


Selected publications
Original research publications
Metzger U, Schall C, Zocher G, Unsöld I, Stec E, Li SM, Heide L, Stehle T (2009) The structure of dimethylallyl tryptophan synthase reveals a common architecture of aromatic prenyltransferases in fungi and bacteria. Proc Nat Acad Sci (USA) 106:14309-14314
Saleh O, Gust B, Boll B, Fiedler HP, Heide L (2009) Aromatic prenylation in phenazine biosynthesis: dihydrophenazine-1-carboxylate dimethylallyltransferase from Streptomyces anulatus. J Biol Chem 284:14439-14447
Dangel V, Härle J, Goerke C, Wolz C, Gust B, Pernodet JL, Heide L (2009) Transcriptional regulation of the novobiocin biosynthetic gene cluster. Microbiology 155: 4025-4035
Anderle C, Hennig S, Kammerer B, Li S-M, Wessjohann L, Gust B, Heide L (2007) Improved mutasynthetic approaches for the production of modified aminocoumarin antibiotics. Chem & Biol 14: 955–967
Pojer F, Wemakor E, Kammerer B, Chen H, Walsh CT, Li S-M, Heide L (2003) CloQ, a prenyltransferase involved in clorobiocin biosynthesis. Proc Natl Acad Sci. (USA) 100: 2316-2321
Review articles
Heide L (2009) The aminocoumarins: biosynthesis and biology. Nat Prod Rep 26:1241-1250.
Heide L (2009) Prenyl transfer to aromatic substrates: genetics and enzymology. Curr Opin Chem Biol 13: 171-179.
Heide L (2009) Aminocoumarins: Mutasynthesis, chemoenzymatic synthesis and metabolic engineering. Meth Enzymol. 459: 437-455
Heide L, Gust B, Anderle C, Li S-M (2008): Combinatorial biosynthesis, metabolic engineering and mutasynthesis for the generation of new aminocoumarin antibiotics. Curr Top Med Chem 8: 667-779.
Li S-M, Heide L (2005) New aminocoumarin antibiotics from genetically engineered Streptomyces strains. Curr Med Chem 12, 763-771

Copyright © 2016上海交通大学分子微生物学研究室

地址:上海市华山路1954号上海交通大学哲生馆(原科学馆)  电话:021-62932943