Linquan Bai
Biochemistry and Molecular Biology



Linquan Bai was born in Shandong, China in 1971. He received his BSc in microbiology from Shandong University (1992). Following his MS and PhD studies respectively with Professor Qi Zhou and Professor Zixin Deng in Huazhong Agricultural University, he had spent three years as a postdoctoral research associate in the laboratory of Professor H. G. Floss at the University of Washington, Seattle, USA. In 2002 he started his academic career as an Associate Professor at the School of Life Sciences & Biotechnology, Shanghai Jiao Tong University. In the winter of 2006, he had spent 4 months on antibiotic regulation as a visiting scholar in Professor Wolfgang Wohlleben’s laboratory at University of Tuebingen, Germany. In 2008, he was appointed as full Professor of Microbiology. His research interests include understanding biosynthetic and regulatory mechanisms of microbial secondary metabolism, pathway engineering and synthetic biology, and functional genomics of antibiotic producers.


Research Direction:  Microbial functional genomics, Antibiotic biosynthesis and regulation

Figure 1. Genomic and transcriptomic insights into the thermo-regulated biosynthesis of validamycin in Streptomyces hygroscopicus 5008. [Wu, et al. BMC Genomics, 2012]

Figure 2. Dual carbamoylations on the polyketide and glycosyl moiety by Asm21 result in extended ansamitocin biosynthesis. [Li, et al. Chemistry & Biology, 2011]

Figure 3. Alternative epimerization in C7N-aminocyclitol biosynthesis is catalyzed by ValD, a large protein of the vicinal oxygen chelate superfamily. [Xu, et al. Chemistry & Biology, 2009]


Selected Publications:

18. Tan GY, Bai L*, Zhong JJ*. Exogenous 1,4-butyrolactone stimulates A-factor-like cascade and validamycin biosynthesis in Streptomyces hygroscopicus 5008. Biotechnol Bioeng. 2013 May 23. doi: 10.1002/bit.24965.
17. Wu H, Qu S, Lu C, Zheng H, Zhou X, Bai L*, Deng Z. Genomic and transcriptomic insights into the thermo-regulated biosynthesis of validamycin in Streptomyces hygroscopicus 5008. BMC Genomics. 2012, 13:337.
16. Zheng L, Zhou X, Zhang H, Ji X, Li L, Huang L, Bai L*, Zhang H*. Structural and functional analysis of validoxylamine A 7'-phosphate synthase ValL involved in validamycin A biosynthesis. PLoS One. 2012, 7(2):e32033.
15. Li Y, Zhao P, Kang Q, Ma J, Bai L*, Deng Z. Dual carbamoylations on the polyketide and glycosyl moiety by asm21 result in extended ansamitocin biosynthesis. Chem Biol, 2011, 18(12):1571-80.
14. Kang Q, Shen Y, Bai L*. Biosynthesis of 3,5-AHBA-derived natural products. Nat Prod Rep, 2012, 29(2):243-63.
13. Jiang C, Wang H, Kang Q, Liu J, Bai L*. Cloning and characterization of the polyether salinomycin biosynthesis gene cluster of Streptomyces albus XM211. Appl Environ Microbiol, 2012, 78(4):994-1003.
12. Zhou X, Wu H, Li Z, Zhou X, Bai L*, Deng Z. Over-expression of UDP-glucose pyrophosphorylase increases validamycin A but decreases validoxylamine A production in Streptomyces hygroscopicus var. jinggangensis 5008. Metab Eng, 2011, 13(6):768-76.
11. Kang Q, Bai L*, Deng Z. Toward steadfast growth of antibiotic research in China: from natural products to engineered biosynthesis. Biotechnol Adv, 2012, 30(6):1228-41.
10. Qiu J, Zhuo Y, Zhu D, Zhou X, Zhang L, Bai L*, Deng Z. Overexpression of the ABC transporter AvtAB increases avermectin production in Streptomyces avermitilis. Appl Microbiol Biotechnol, 2011, 92(2):337-45.
9. Wu Y, Kang Q, Shang G, Spiteller P, Carroll B, Yu TW, Su W, Bai L*, Floss HG. N-methylation of the amide bond by methyltransferase asm10 in ansamitocin biosynthesis. Chembiochem, 2011, 12(11):1759-66.
8. Wu Y, Kang Q, Shen Y, Su W, Bai L*. Cloning and functional analysis of the naphthomycin biosynthetic gene cluster in Streptomyces sp. CS. Mol Biosyst, 2011, 7(8):2459-69.
7. Wu Q, Liang J, Lin S, Zhou X, Bai L*, Deng Z, Wang Z*. Characterization of the biosynthesis gene cluster for the pyrrole polyether antibiotic calcimycin (A23187) in Streptomyces chartreusis NRRL 3882. Antimicrob Agents Chemother, 2011, 55(3):974-82.
6. He Y, Sun Y, Liu T, Zhou X, Bai L*, Deng Z. Cloning of separate meilingmycin biosynthesis gene clusters by use of acyltransferase-ketoreductase didomain PCR amplification. Appl Environ Microbiol, 2010, 76(10):3283-92.
5. Xu H, Zhang Y, Yang J, Mahmud T*, Bai L*, Deng Z. Alternative epimerization in C7N-aminocyclitol biosynthesis is catalyzed by ValD, a large protein of thevicinal oxygen chelate superfamily. Chem Biol, 2009, 16(5):567-76.
4. Zhang Y, Bai L*, Deng Z. Functional characterization of the first two actinomycete 4-amino-4-deoxychorismate lyase genes. Microbiology, 2009, 155(Pt7):2450-9.
3. Zhou Y, Meng Q, You D, Li J, Chen S, Ding D, Zhou X, Zhou H*, Bai L*, Deng Z. Selective removal of aberrant extender units by a type II thioesterase for efficient FR-008/candicidin biosynthesis in Streptomyces sp. strain FR-008. Appl Environ Microbiol, 2008, 74(23):7235-42.
2. Xu H, Yang J, Bai L*, Deng Z, Mahmud T*. Genetically engineered production of 1,1'-bis-valienamine and validienamycin in Streptomyces hygroscopicus and their conversion to valienamine. Appl Microbiol Biotechnol, 2009, 81(5):895-902.
1. Zhao P, Bai L*, Ma J, Zeng Y, Li L, Zhang Y, Lu C, Dai H, Wu Z, Li Y, Wu X, Chen G, Hao X, Shen Y*, Deng Z, Floss HG. Amide N-glycosylation by Asm25, an N-glycosyltransferase of ansamitocins. Chem Biol, 2008, 15(8):863-74

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