Qianjin Kang
Associate professor
Biosynthesis of Antitumor Antibiotics
Email: qjkang@sjtu.edu.cn

Qianjin Kang was born in Anhui province of P. R. China in 1981. He received his BSc on Traditional Chinese Pharmacology from Anhui College of Traditional Chinese Medicine in 2003. He obtained his PhD in 2008 under the guidance of Prof. Yuemao Shen at Kunming Institute of Botany, Chinese Academy of Sciences and then joined Prof. Zixin Deng's group at the Shanghai Jiao Tong University for postdoctoral research. At the end of 2010, he joined Shanghai Jiao Tong University as a Research Assistant of Biochemistry and Molecular Biology. At the beginning of 2013, he promoted to Associate professor in SJTU. His current research includes the biosynthesis and synthetic biology investigations on microorganism-originated natural products, and genome mining of novel natural antibiotics from special microorganisms.
 
Research Interests
1、 Biosynthesis and synthetic biology investigations on microorganism-originated natural products;
2、 Studies on enzymatic tailoring mechanismofmicroorganism-originatednatural products;
3、 Genome mining of novel natural antibiotics from special microorganisms.

Figure 1  (A) Different AHBA biosynthetic gene clusters . (B) Phylogenetic analysis of AHBA synthases. (Kang, et al. Nat Prod Rep. 2012)

Figure 2  Genes involved in dtx biosynthesis in M. robertsii. (Wang, et al.  Proc Natl Acad Sci USA. 2012)

Figure 3   Structures of thiopeptides. (Kang, et al. Biotechnol Adv. 2012)
 
Education Experience
2003.09-2008.06   Ph.D., State Key Laboratory of phytochemistry and plant resources in west China, Kunming Institute of Botany, 
                                 Chinese Academy  of  Sciences
1999.09-2003.06   Anhui University of Traditional Chinese Medicine

Work Experience 
2013.01- Now       Associate professor, SJTU, China  
2010.12-2012. 12  Assistant Researcher, SJTU, China
2008.07-2010.11   Post-doctor, SJTU, China   
 
Honors
1.   2012.12, SMC- Chenxing Young Scholars Program for outstanding young teacher in SJTU (B) 
2.   2011.12, SMC- Chenxing Young Scholars Program for outstanding young teacher in SJTU (C)
 
Selected Publications：
1. Biosynthesis of 3,5-AHBA-derived natural products. Kang Qianjin, Shen Yuemao, and Bai Linquan*, Nat Prod Rep, 2012, 29: 243-263.
2. Unveiling the Biosynthetic Puzzle of Destruxins in Metarhizium Species. Wang, Bing, Kang, Qianjin, Lu, Yuzhen; Bai, Linquan, and Wang, Chengshu*, Proc Natl Acad Sci USA, 2012, 109: 1287-1292.
3. Toward steadfast growth of antibiotic research in China: From natural products to engineered biosynthesis. Kang Qianjin, Bai Linquan*, and Deng Zixin, Biotechnol Adv,2012, 30(6):1228-41
4. Cloning and functional analysis of the naphthomycin biosynthetic gene cluster in Streptomyces sp. CS. Wu Yingying, Kang Qianjin (co-first author), Shen Yuemao, Su Wenjin and Bai Linquan*, Mol Biosyst., 2011, 7: 2459-2469. 
5. N-methylation of the Amide Bond by Methyltransferase Asm10 in Ansamitocin Biosynthesis. Wu Yingying, Kang Qianjin (co-first author), Shang Guangdong, Spiteller Peter, Carroll Brian, Yu Tin-Wein, Su Wenjin, Bai Linquan*, and Floss Heinz G., Chembiochem, 2011, 12: 1759-1766.
6. Chemical Constituents from the Stem Bark of Trewia nudiflora L. and their Antioxidant Activities. Kang Qianjin, Yang Xianwen, Wu shaohua, Ma Yanling, Li Ling, and Shen Yuemao*, Planta Medica, 2008, 74: 445-448.
7. Cardenolides and Cardiac Aglycone from the Stem Bark of Trewia nudiflora L. Kang Qianjin, Zhao Peijin, He Hongping, and Shen Yuemao*, Helv Chim Acta, 2005, 88: 2781-2787.
8. Cloning and Characterization of the Polyether Salinomycin Biosynthesis Gene Cluster of Streptomyces albus XM211. Jiang Chunyan , Wang Hougen, Kang Qianjin, Liu Jing and Bai Linquan*, Appl. Environ. Microbiol.2012, 78(4):994.
9. Dual carbamoylations on the polyketide and glycosyl moiety by Asm21 result in extended ansamitocin biosynthesis. Li Yan, Zhao Peiji, Kang Qianjin, Ma Juan, Bai Linquan*, et al., Chem Biol., 2011, 18: 1571-1580. 
10. Elucidation of Piericidin A1 biosynthetic locus revealed a thioesterase-dependent mechanism of α-pyridone ring formation. Liu Qian, Yao Fen, Chooi Yit Heng, Kang Qianjin, Xu Wei, et al. You Delin*. Chem Biol. 2012, 24;19(2):243-53.
11. Characterization of the Azinomycin  B  Biosynthetic Gene Cluster Revealing a Different Iterative Type I Polyketide Synthase for Naphthoate Niosynthesis. Zhao Qunfei, He Qingli, Ding Wei, Tang Mancheng, Kang Qianjin, Yu Yi, Deng Wei, Zhang Qi, Fang Jie, Tang Gongli, and Liu Wen.  Chem Biol., 2008, 15:693-705.