Lutz Heide
Professor
Natural Products Biosynthesis
Email: heide@uni-tuebingen.de
Professor Dr. rer. nat. Lutz Heide
Pharmaceutical Institute, University of Tübingen, 72076 Tübingen, Germany
www.uni-tuebingen.de/pharmazie/arbeitskreise/biologie/research.html
Personal Details Contact Details
Date of Birth: 16th May 1955 Telephone: +49-7071-2972460
Nationality: German FAX: +44-7071-295250
E-mail: heide@uni-tuebingen.de
Education and Research Experience
Licensed Pharmacist, University of Münster, Germany, 1978
Ph.D. Plant and Bacterial Metabolism, University of Münster, 1981 (E. Leistner)
Senior Pharmacist Adviser, Ministry of Health, Somalia, 1982-85
PostDoc (Humboldt Fellow), Plant Biotechnology, Kyoto University, Japan, 1985-87 (M. Tabata)
Assistant Professor, Pharmaceutical Biology, University of Bonn, Germany, 1987-90
DFG Heisenberg Scholar, University of Bonn, Germany, 1990-91
Associate Professor, Pharmaceutical Biology, University of Freiburg, Germany, 1991-94
Full Professor (C4), Pharmaceutical Biology , University of Tübingen, Germany, 1994-present
April-Sep. 1996: Sabbatical with Dr. H. G. Floss, University of Washington, Seattle, USA
March-Sep.2005 Sabbatical with Prof. J. Noel, Salk Insitute, La Jolla, California, USA
Research theme: Genetic engineering of antibiotic biosynthesis in Streptomyces
Professional activities (selected)
2007-present Associate Editor of Microbiology
2004-2007 Coordinator of the EC-funded Research Consortium CombiGyrase
2004-present Member of the Selection Committees of the German Academic Exchange Service (DAAD) for the Asia/Pacific Region
2007-2008 Member of the International Scientific Committee of the International Biotechnology Symposium, Dalian, China
2008-2009 Member of the International Advisory Board of the Fifteenth International Symposium on the Biology of Actinomycetes (ISBA'15), Shanghai, China
Selected research grants
European Community, Integrated Project No. 005224 “ActinoGEN: Integrating Genomics-Based Applications to Exploit Actinomycetes as a Resource for New Antibiotics”. Coordinator P. Dyson, Swansea, UK. Total Budget € 9.4 M, Tübingen Budget € 0.95 M.
European Community, Specific targeted research projec No. 503466 “CombiGyrase: Development of new gyrase inhibitors by combinatorial biosynthesis”. Coordinator L. Heide, Tübingen, Germany. Total Budget € 1.6 M, Tübingen Budget € 0.33 M
German Research Foundation (DFG), Collaborative Research Center 766 “The Bacterial Cell Envelope: Structure, Function and Infection Interface”: “Influx and efflux of new aminocoumarin derivatives across the bacterial cell envelope”. With K. Hantke. € 0.4 M.
German Research Foundation (DFG), Priority Progamme SPP 1152 “Evolution of metabolic diversity”: “Evolution of a new class of aromatic prenyltransferases of secondary metabolism”. € 0.3 M.
Selected publications
Original research publications
Metzger U, Schall C, Zocher G, Unsöld I, Stec E, Li SM, Heide L, Stehle T (2009) The structure of dimethylallyl tryptophan synthase reveals a common architecture of aromatic prenyltransferases in fungi and bacteria. Proc Nat Acad Sci (USA) 106:14309-14314
Saleh O, Gust B, Boll B, Fiedler HP, Heide L (2009) Aromatic prenylation in phenazine biosynthesis: dihydrophenazine-1-carboxylate dimethylallyltransferase from Streptomyces anulatus. J Biol Chem 284:14439-14447
Dangel V, Härle J, Goerke C, Wolz C, Gust B, Pernodet JL, Heide L (2009) Transcriptional regulation of the novobiocin biosynthetic gene cluster. Microbiology 155: 4025-4035
Anderle C, Hennig S, Kammerer B, Li S-M, Wessjohann L, Gust B, Heide L (2007) Improved mutasynthetic approaches for the production of modified aminocoumarin antibiotics. Chem & Biol 14: 955–967
Pojer F, Wemakor E, Kammerer B, Chen H, Walsh CT, Li S-M, Heide L (2003) CloQ, a prenyltransferase involved in clorobiocin biosynthesis. Proc Natl Acad Sci. (USA) 100: 2316-2321
Review articles
Heide L (2009) The aminocoumarins: biosynthesis and biology. Nat Prod Rep 26:1241-1250.
Heide L (2009) Prenyl transfer to aromatic substrates: genetics and enzymology. Curr Opin Chem Biol 13: 171-179.
Heide L (2009) Aminocoumarins: Mutasynthesis, chemoenzymatic synthesis and metabolic engineering. Meth Enzymol. 459: 437-455
Heide L, Gust B, Anderle C, Li S-M (2008): Combinatorial biosynthesis, metabolic engineering and mutasynthesis for the generation of new aminocoumarin antibiotics. Curr Top Med Chem 8: 667-779.
Li S-M, Heide L (2005) New aminocoumarin antibiotics from genetically engineered Streptomyces strains. Curr Med Chem 12, 763-771
Copyright © 2016，The Laboratory of Molecular Microbiology at Shanghai Jiao Tong University. All rights reserved.
Add：Science Building, Xuhui Campus, Shanghai Jiaotong University, Shanghai 200030, China. Tel：021-62932943